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Glykosidasen: Neues für die „Zuckerforscher“New England Biolabs (NEB) offers a selection of endoglycosidases and exoglycosidases for glycobiology research. Many of these reagents are recombinant, and all undergo several quality control assays, enabling us to provide products with lower unit cost, high purity and reduced lot-to-lot variation. All of our glycosidases are tested for contaminants. Since p-nitrophenyl-glycosides are not hydrolyzed by some exoglycosidases, we use only fluorescently-labeled oligosaccharides to screen for contaminating glycosidases. |
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Glycobiology is the study of the structure, function and biology of carbohydrates, also called glycans, which are widely distributed in nature. It is a small but rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Proteomics, the systematic study of proteins in biological systems, has expanded the knowledge of protein expression, modification, interaction and function. However, in eukaryotic cells the majority of proteins are posttranslationally modified. Glycosylation defines the adhesive properties of glycoconjugates and it is largely through glycan–protein interactions that cell–cell and cell–pathogen contacts occur, a fact that accentuates the importance of glycobiology. Glycomics, the study of glycan expression in biological systems, relies on effective enzymatic and analytical techniques for correlation of glycan structure with function. |
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