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NEW: SARS-CoV-2 Rapid Colorimetric LAMP Assay Kit
The SARS-CoV-2 Rapid Colorimetric LAMP Assay Kit utilizes isothermal amplification for use in the analysis of SARS-CoV-2, the novel coronavirus that causes COVID-19.
- Colorimetric LAMP enables simple, visual detection (pink-to-yellow) of amplification of SARS-CoV-2 nucleic acid
- Set up reactions quickly and easily, using a simple heat source and unique WarmStart technology
- Reduce risk of carryover contamination, with UDG and dUTP included in the master mix
- Assay targets N and E regions of the SARS-CoV-2 genome, for optimized sensitivity and specificity
- Bring confidence to your results using the provided controls
* Research Use Only
Selected current publications and pre-prints on Covid-19 research with NEB products:
Enhancing colorimetric loop-mediated isothermal amplification speed and sensitivity with guanidine chloride
Yinhua Zhang, et al. (New England Biolabs), Biotechniques 2020 Jul 8.
Learn how NEB optimized Colorimetric Covid-19 LAMP Assay using new Primersets and Guanidine Hydrochlorid. This Paper is the basis for the new SARS-CoV-2 Rapid Colorimetric LAMP Assay Kit (#E2019)
A direct RT-qPCR approach to test large numbers of individuals for SARS-CoV-2
Maricic et al., MedRxiv 2020 Jun 26.
Authors from the MPI for evolutionary Anthropology in Leipzig present a cheap and fast approach to detect SARS-CoV-2 in single or pooled gargle lavages (‘mouthwashes’), using NEBs Luna Universal RT-qPCR Mastermix. Direct RT-qPCR of pooled mouthwashes is discussed as a scalable option for surveillance testing.
Scalable, rapid and highly sensitive isothermal detection of SARS-CoV-2 for laboratory and home testing
Kellner et al., BioRxiv 2020 Jun 23.
Scientists at the IMP Vienna establish a sensitive and robust colorimetric LAMP assay with NEB Bst Polymerases, reverse Transcriptase RTx and UDG. The combination is now available as convenient mastermix format (M1804). Optimizations include: multiplex primersets, a quick extraction/enrichment protocol with carboxy-beads (Bead-LAMP) and the alternative dye hydroxy-naphtol-blue HNB for colorimetric detection.
Rapid SARS-CoV-2 testing in primary material based on a novel multiplex LAMP assay
Bernhard Schermer et al., MedRxiv 2020 Jun 22.
The group at the University Hospital Cologne published a LAMP assay for Covid-19 detection, optimized by multiplex primer sets for detection and compares LAMP with Cas-Nuclease-based SHERLOCK Assay. The more sensitive LAMP assay is then discussed as prime-option for the development of easy and cheap POC test kits.
LAMP-Seq: Population-Scale COVID-19 Diagnostics Using Combinatorial Barcoding
Jonathan Schmid-Burgk et al., BioRxiv 2020 Jun 08.
The University Hospital in Bonn develops a promising approach for population-wide testing. Automated RT-LAMP with NEB’s Mastermix includes sample-specific barcodes, reactions are massively pooled and amplified barcodes (i.e. positive samples) are identified by next generation sequencing.
Screening for SARS-CoV-2 infections with colorimetric RT-LAMP and LAMP sequencing
Dao Thi et al., Science Translational Medicine 12 Aug 2020, Vol. 12, Issue 556
Universtity Hospital and DKFZ in Heidelberg establish Colorimetric LAMP for Covid-19 surveillance testing. Sensitivity of LAMP on extracted RNA and unpurified swab samples are compared.